Immunology and Cell Biology

Microbial Parasitic and Fungal Immunology

Here, in order to identify novel immunological signals of latent tuberculosis infection (LTBI) and comprehend the phenotypic of tuberculosis (TB)-specific T cells, we used a cell population transcriptomics technique to sort human memory CD8 T cells.

We discovered a 41-gene profile that could distinguish memory CD8 T cells from uninfected controls and healthy LTBI participants. The majority of the genes in the gene signature were known to be linked to mucosal associated invariant T cells (MAITs), which was consistent with the reduced frequency of MAITs found in LTBI patients.