Costimmulatory pathways in multiple sclerosis

Costimulatory molecules can be categorized based either on their functional attributes or on their structure. The costimulatory molecules discussed in this review will be divided into (1) positive costimulatory pathways: promoting T cell activation, survival and/or differentiation; (2) negative costimulatory pathways:antagonizing TCR signalling and suppressing T cell activation; (3) as third group we will discuss the members of the TIM family, a rather “new” family of cell surface molecules involved in the regulation of T cell differentiation and Treg function. Costimulatory pathways have a critical role in the regulation of alloreactivity.  A complex network of positive and negative pathways regulates T cell responses.  Blocking costimulation improves allograft survival in rodents and non-human primates. The costimulation blocker belatacept is being developed as immunosuppressive drug in renal transplantation.

  • T-cell costimulation
  • CD27,CD70, CD40, CD40L costimmulatory pathways
  • PD1, PD -L1 pathway
  • Co-inhibitory pathways
  • Novel costimulatory pathways

Related Conference of Costimmulatory pathways in multiple sclerosis

September 13-14, 2018

11th Annual Congress on Immunology & Immunotechnology

Zurich, Switzerland
September 17-18, 2018

3rd International Conference on Tumor & Cancer Immunology and Immunotherapy

San Diego, California, USA
September 17-18, 2018

3rd International Conference on Tumor & Cancer Immunology and Immunotherapy

San Diego, California, USA
September 20-21, 2018

Global Meet on Immunology and Molecular Biology

Oslo, Norway
October 19-20, 2018

10th World Congress and Expo on Immunology

New York, USA
October 29-30, 2018

6th International Conference on HIV/AIDS, STDs and STIs

San Francisco, USA
November 22-23, 2018

World Conference on Vaccine and Immunology

Bucharest, Romania
November 26-27, 2018

3rd International Conference on Autoimmunity

Dublin, Ireland
December 06-08, 2018

Annual Congress and Expo on Antibiotics

Amsterdam, Netherlands
March 04-05, 2019

10th Molecular Immunology & Immunogenetics Congress

Barcelona, Spain
March 18-19, 2019

11th Global Summit on Immunology and Cell Biology

Sydney, Australia
June 13-14, 2019 |

10th European Immunology Conference

Berlin, Germany

Costimmulatory pathways in multiple sclerosis Conference Speakers

Recommended Sessions

Related Journals

Are you interested in