Immunology and Cell Biology

Haematopoietic and Lymphoid Malignancies and Immune System Development

Haematopoietic and lymphoid malignancies are tumors that affect the blood, bone marrow, lymph, and lymphatic system. Malignancies of the hematopoietic and lymphoid tissues include the leukemias, myeloproliferative neoplasms, plasma cell dyscrasias and dendritic cell neoplasms.

Immune system

The immune system plays a dual role against cancer: it prevents tumor cell outgrowth and also sculpts the immunogenicity of the tumor cells. Cancer cells are able to escape from the immune system by inhibiting T lymphocytes activation. New immunotherapies have been developed to target these T lymphocytes activation modulators: the immune checkpoints, defined as molecules of immune system that either turn up a signal or turn down a signal. Most of the cancers protect themselves from immune system by inhibiting activation of T cell.