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Wen Qiu


Wen Qiu

Nanjing Medical University, China

Biography

Wen Qiu is currently an Associate Professor at Department of Immunology of Nanjing Medical University. He is exploring the roles and mechanisms of complement especially C5b-9 in the induction of glomerular mesangial cell (GMC) apoptosis, inflammation and proliferation in rat Thy-1 nephritis as a widely used model of human mesangial proliferative glomerulonephritis (MsPGN) as well as the roles and mechanisms of IL-17 in astrocyte pathological changes in EAE mice. These include signal transduction, microRNA regulation, and transcriptional factor regulation. He is also exploring the effects of post-transcriptional regulation such as ubiquitination and acetylation on the activation of signaling molecules, transcription factors and histones.

Abstract

Abstract : Sublytic C5b-9 induces glomerular mesangial cell apoptosis through the cascade pathway of MEKK2-p38 MAPK-IRF-1-TRADD-Caspase 8 in rat Thy-1 nephritis