9^th European Immunology Conference associated with Antibody Engineering Meeting

My talk is an overview of our interests in translational outcomes research in infl ammation immunobiology and regenerative medicine and includes: novel format nanoantibodies are engineered to develop diagnostic reagents; nano-particles are synthesized to act as vehicles in drug discovery studies; nanopolymers are designed to act as bio-scaffolds for homing of tissue engineered pluripotent cells into degenerate lesions and; nano-conjugates in multi-purpose applications in acute and chronic inflammation. 1. Camelid antibodies - We have successfully generated proof-of-concept of a platform technology and functionally active viable anti-alkaline phosphatase and alpha amylase antibodies. Under-development are anti-OVA-specifi c IgE antibodies for treatment of allergic asthma. 2. Mesoporous carbon nanoparticles are a library of nanomaterials useful as bioimaging probe and as drug delivery carriers. 3. Nano-compounds and nano-scaff old matrices were developed from Cyamopsis tetragonoloba, an edible polysaccharide with a galactomannan component. Carboxymethyl guar gum was synthesized in homogeneous phase and macroporous 3D scaffolds designed for tissue engineering. 4. Multi-purpose application in biotechnology of guar gum (GG) - applications tested successfully with guar-nano, guar-peptide, guar-quarcetin as antiinflammatoryy compounds are:bioimagingg, biomolecular interaction, and cellular endocytosis studies. Our lab mandate is translation from bench to bedside, from lab to field. Translational studies encompassing cross-disciplinary collaborations and constant technology upgradation and relevance remains our constant endeavor. A number of processes and products have been patented and plans are on for their direct application for improvement of human and veterinary health and disease.