5^th European Immunology Conference

Biography

Biography: Mokhtar Mokhtari

Abstract

Medicinal plants are believed to be an important source of new chemical substances with potential therapeutic effects. The aim of the present study was to evaluate the anti inflammatory effect of oral administration of Oliveria decumbens hyroalcholic extract by Carageenan tests in rats. In this research, 60 male Wistar rats weighing about 210±20 grams were divided into ten group (n=6) for evaluation of antinociceptive effects the formalin test induced pain. The nociceptive response develops two phase: First (0-5) min after formalin (first or acute phase) and (16-60) min after formalin injection (second or chronic phase). The animals pre-treated with oral dose of extracts (100, 200, 400 mg/kg), 60 min before administration formalin for anti-inflammatory effects, the carrageenan induced hind paw edema model in rats were used and the animals pre-treated with oral dose of extracts (100, 200, 400 mg/kg), 30 min before administration of carrageenan. The control group is without receiving any drug and the sham group receiving an equal volume from distilled water. Then the paw volume measured in the mercury from 0 to 2 hours and 30 min after carrageenan injection statistical analysis by ANOVA and T-Test used (p<0/05). Results shows there is decreased pain and inflammation in formalin and carrageenan tests in the group that received 400 mg/kg dose of extract in comparison with the control and sham groups (p<0.05). This results demonstrated extract dose-dependently following the receipt of formalin resulted in a decrease of nociceptive in acute and chronic phase. There is decreased nociception in chronic and acute phase of formalin test in the group that received only 400 (mg/kg) of extract. So, data shows there is decreased inflammation in Carrageenan test in the group that received 400 (mg/kg) dose of extract in comparison with the control and sham groups (P 0.05).