Immunology and Radiotherapy

Cytokines and Chemokine’s and Their Receptors

The immune system is able to communicate well and is built to react swiftly, decisively, and globally to defend an organism against pathogens and outside invaders. The immune system is created and controlled by the cytokine superfamily of proteins, which is a crucial component of the cell signalling network. Recent years have seen significant advancements in our understanding of how cytokines and chemotactic cytokines interact with or influence the immune system.

The techniques utilised to regulate the intensity and duration of signalling are covered in this chapter along with the activation of the Janus kinase/signal transducers and activators of transcription pathway. It focuses on the family of proteins called suppressor of cytokine signalling, which functions as a negative feedback loop to shut down signal transduction. Additionally, it provides a brief overview of the other important signalling pathways that members of the transforming growth factor family and the tumour necrosis factor family employ. Additionally, G-protein-coupled chemokine receptor signalling by chemokine’s is reported.