6^th International Conference and Expo on Immunology October 24-25, 2016 Chicago,IL, USA

Charles J Malemud received the PhD from George Washington University in 1973 and completed postdoctoral studies at the State University of New York at Stony Brook in 1977. He is Professor of Medicine & Anatomy in the Division of Rheumatic Diseases and Senior Investigator in the Arthritis Research Laboratory at Case Western Reserve University School of Medicine. He has published more than 200 papers and reviews primarily in the field of chondrocyte biology. He is on the editorial board of several rheumatology, immunology and musculoskeletal journals and is Editor-in-Chief of the Journal of Clinical and Cellular Immunology.

Biology of the Musculoskeletal System Intracellular Signal Transduction Pathways Inflammation Pro-inflammatory, Anti-Inflammatory & Anabolic Cytokines Apoptosis Matrix metalloproteinases Osteoarthritis Rheumatoid Arthritis Fibromyalgia Autoimmune Disorders Research Interest

Dr. Vajdy is a Mucosal Immunologist with over 20 years of direct experience in designing mucosal and systemic adjuvants and vaccines, studying mucosal and systemic B and T cell immune induction mechanisms and long-term immunological memory. Following Ph.D. studentship at Goteborg University under the supervision of Dr. Nils Lycke, a prominent Mucosal Immunologist, Dr. Vajdy completed his first post doctoral fellowship with Dr. Katherine Knight, then President of the American Association of Immunologists. Dr. Vajdy completed his second post doctoral fellowship with Dr. Marian Neutra, an expert in Mucosal Biology and M cells of the intestinal Peyer’s patches. Dr. Vajdy was recruited to Chiron Corporation and Novartis Vaccines and Diagnostics where he remained for 9.5 years with increasing responsibilities including project leadership for a vaccine manufacturing platform technology. He also held simultaneous academic positions as Adjunct Clinical Assistant Professor with the Department of Internal Medicine, Division of Infectious Diseases and visitingassociate professor at Department of Medical Microbiology and Immunology, University of California, Davis. He was also a Faculty Member with the Graduate Group, Department of Comparative Pathology, University of California, Davis. In these capacities, he trained a Ph.D. student and 3 post-doctoral fellows and wrote collaborative NIH grants. Dr. Vajdy has authored 50 papers and manuscripts, 45 of which have been published and the remaining are submitted or are in manuscript form. Dr. Vajdy is the editor of a book entitled “immunity against mucosal pathogens” (Springer, 2008). Dr. Vajdy was the PI and recipient of an R21 grant (R21 AI50430-01). He was also an investigator on several multi-project NIH grants. Dr. Vajdy is the inventor of 6 patents owned by Novartis Vaccines as well as one patent owned fully by EpitoGenesis Inc.

Mucosal Immunology, Vaccines

I am Oliver, Associate Professor in Unit for Laboratory Animal Medicine (ULAM) and Department of Microbiology and Immunology. I am also an affiliated member of the Center for Computational Medicine and Biology (CCMB) and a member of the (Comprehensive Cancer Center) in the University of Michigan (UM) Medical School. Our laboratory research is focused on host-Brucella interaction and bioinformatics. I had my D.V.M. education at Jiangxi Agricultural University and my M.S. degree (Co-advisors: Professors Zhongzhi Zhang and Hanchun Yang) in Infectious Diseases and Veterinary Preventive Medicine at China Agricultural University in China. I obtained my professional assistant veterinarian license during my two-year employment at Beijing Xijiao Livestock and Poultry Company, Beijing, China. My training in Brucella research started in 1996 in Dr. Gerhardt Schurig’s immunology laboratory at the Virginia Polytechnic Institute and State University (Virginia Tech). I obtained my Ph.D. in Dr. Schurig's lab in 2000. I then worked in the same lab as a postdoc for half a year. I obtained my M.S. degree (research advisor: Dr. Pedro Mendes) in computer science in Virginia Tech with a focus on bioinformatics in May 2002. After graduation I worked as a senior research associate for three years in Dr. Bruno Sobral’s group at the Virginia Bioinformatics Institute (VBI). I joined UM in July 2005 as an assistant professor and became an associate professor in September 2011 (with tenure).

Yongqun Oliver research interest are Brucella pathogenesis, vaccine research and development and Bioinformatics.

Michael G. Hanna, Jr. received his PhD in experimental pathology and immunology from the University of Tennessee in 1964. He was on staff of the Oak Ridge National Laboratory, biology division from 1964-75. During this period he pioneered the early concepts of tumor immunology. He also served as a consultant with NASA for the lunar receiving laboratory during Apollo 11 and 12, for which his expertise in immunology was used in the testing of the lunar core powder for immunogenic or pathogenic materials. Dr. Hanna served during1975–83 as Director of the National Cancer Institute, Frederick Cancer Research Center (MD, USA). In this position he created a center of research excellence for the NCI and established the Biological Response Modifier Program which led in the development of resources for immunotherapy of cancer. He was Chief Operating Officer during 1984–94 of Organon Teknika/Biotechnology Research Institute and Senior Vice President of Organon Teknika Corporation, a subsidiary of Akzo Nobel, The Netherlands. He developed and obtained approvals for TICE BCG for the treatment of carcinoma in situ (CIS) bladder cancer, which remains the standard of care for prophylaxis of recurrence of superficial bladder cancer and therapy of CIS. Subsequently, Dr. Hanna founded PerImmune Inc., for which he served as President and Chief Executive Officer before it merged with Intracel Corp. in1998. He continued to work for Intracel Resources as Chief Scientific Officer and Chairman. In 2007, Dr. Hanna founded Vaccinogen Inc., where he served as Chairman and CEO. Currently, Dr. Hanna is Chairman Emeritus. The company is a pioneer in the field of cancer vaccines and is developing OncoVAX, an autologous vaccine designed to elicit a specific immune response against cancer cells. The Phase III vaccine is being investigated for treatment mainly of colon cancer, but also for melanoma and renal cell carcinoma. In addition to cancer therapy research and development, Dr. Hanna has been involved in Homeland Security. He served as Chairman of the Department of Commerce Biotechnology Advisory Committee (1984–9) and also participated in the Department of Defense Technical Working Group for Biotechnology (1988–9). PerImmune completed a Department of Defense contract to manufacture the current effective therapeutic for Botulinum toxin, an equine heptavalent anti-toxin. Dr Hanna’s research resulted in over 225 publications in international peer-reviewed journals and book chapters, and he holds 10 patents related to immunotherapy. Dr Hanna has been the recipient of numerous honors and awards and has serves on many editorial boards.

Immunology, Vaccines

Ahmed Hegazi (or Ahmed Gaffer Hegazi; احمد جعفر حجازى) (born May 31, 1948) is currently a Professor of Microbiology and Immunology in the department of Zoonotic Diseases, National Research Center, Egypt. Prof. Hegazi received his masters degree in 1979, and his PhD in 1981. Hegazi's research work has been focused lately on bee products and their therapeutic effects. Hegazi Organized and contributed to national and international research projects since 1977 and up till now; he has been the principal investigator on multiple research projects within the National Research Center. He has published 166 scientific papers and articles in national and international journals. He also served on the board of multiple national and international scientific journals. Dr. Hegazi is also the president of the Egyptian Environmental Society for Uses and Production of Bee Products, secretary of the Egyptian Society of Apitherapy, secretary general of the African Federation of Apiculture Associations, and a member of the International Apitherapy Commission (APIMONDIA). Awards First Class Decoration of Excellence, Egypt, 1995 The Senior Scientist Prize of National Research Center, Cairo, Egypt, 1996 The National Scientific Prize In Biological Sciences, Egypt, 1990 The Scientific Prize of The National Research Center, Cairo, Egypt, 1989 The Second Best Research Paper Award, International Congress of Propolis, Bones Airs, Argentina, 2000 Main Speaker Award,10th Academic Conference, PRA and NAS (Nippon Apitherapy Soc.) Japan, 2006 2 Bronze medals from The International Innovation Fair of the Middle East, Kuwait, 2007 Patents Patent No. 8901 at 22/08/2006: A novel drug from natural products with new therapeutic modalities in treatment of psoriasis Patent No. 1005 at 02/01/2006: A novel drug from natural resources for controlling Fascioliasis Patent No. 270: at 01/06/2005: A novel drug from medicinal plants with antiatherosclerotic (hypocholesterolaemic), antioxidant and cardio protective properties. Patent No. 272: at 01/06/2005: A novel drug from natural resources with antiatherosclerotic (hypocholesterolaemic), antioxidant and cardio protective properties. Scientific Activities Editor in the following International Journals: Research Journal of Allergy, 2007 International Journal of Virology, 2007 Current Research In Tuberculosis, 2007 Research Journal of Veterinary Science, 2007 Research Journal of Microbiology, 2007 International Journal of Cancer Research, 2007 Research Journal of Medicinal plants, 2007 Referee in the following International Journals: Journal of Planta Medica, 2005 Journal of Evidence Based Complementary and Alternative Medicine, 2006 International Journal of Radiation Biology, 2007

Apitherapy, Immunology

Mark S. Kindy, Ph.D. is Professor of Neurosciences at the Medical University of South Carolina, Adjunct Professor of Bioengineering at Clemson University, Adjunct Professor of Chemical Engineering at the University of South Carolina, Adjunct Professor of Management and Entreprenurialism, School of Business, College of Charleston. He received his BA in zoology from the University of Massachusetts in 1980. Dr. Kindy received his Ph.D. in Biochemistry from Boston University School of Medicine from 1982-1987. He was a post-doctoral fellow at the Salk Institute from 1987-1989 in Molecular Biology and Virology. From 1989-2002, Dr. Kindy was a faculty member in the Department of Biochemistry at the University of Kentucky and rose from Assistant Professor to Full Professor. Dr. Kindy is currently the Admiral Pihl Endowed Professor in the Department of Neurosciences. Dr. Kindy is also a Research Career Scientist at the Ralph H. Johnson VA Medical Center in Charleston. Dr. Kindy has served on many NIH, AHA, AA review panels, has reviewed for many journals and is currently on the editorial board of 10 journals. Dr. Kindy has over 140 peer reviewed publications and is funded by the NIH, VA , NSF and several foundations.

Mark S. Kindy research interest include Neurological disorders, Biotechnology, Bioengineering, Inflammation, Immune function in disease, Vaccines.

Jagat Kanwar is an Associate Professor of Immunology & Cell Biology, and Group Leader in “Nanomedicine-Laboratory of Immunology and Molecular Biomedical Research” at Deakin University, Australia. He did his PhD in 1993 from PGIMER, Chandigarh, India and worked as a Senior Scientist in The Auckland University, New Zealand for more than 10 years. He has a national and international reputation in investigating fundamental and applied molecular aspects of cancer and chronic inflammation. His research is also focused on miRNA, aptamer, locked nucleic acid (LNA) LNA-modified chimeric aptamers-siRNA conjugates, and immunoliposomes technology and disease targeted drug discovery. His research combines Immunology with state of the art and cutting edge techniques in Molecular Biology, Biochemistry, Nanobiotechnology and visualization to investigate the pathways in which key molecules are regulated in both normal and disease states. He designed nanocarriers for applications in vaccines, immunotherapy, and drug delivery of antigens immunostimulatory ligands to dendritic cells and subsequent stimuli to T- lymphocytes, B-lymphocytes and TH17 cells.

Cancer and chronic inflammatory diseases targeted nanomedicine based drug delivery siRNA, miRNA anti-sense targeted gene nanomedicine based technology to target cancer and inflammation Drug discovery with anticancer targets for cancer cell survival, death, arrest, and repair Development of recombinant proteins and searching new immunomodulatory and anti-inflammatory bioactives, proteins and peptides for cancer and neuroprotection Development of complementary alternative medicine from the milk derived proteins including metal binding protein (Lactoferrin), and herbal preparation derived active components with a special focus on the treatment of colon and breast cancers Development of oral and intravenous administration of nanocarriers to overcome the challenging concept of drug resistance in various cancers Development of new generation safe, biodegradable, less toxic, disease targeted natural contrast materials for imaging Novel nano-medicinal based vaccines and immunotherapy Micro-fluidics and Lab-on-a-Chip devices for delivery and diagnosis

James Mansfield is a scientist with over 25 years of experience in spectral imaging,in-vivo spectroscopy and applied data analysis, directed towards finding of novel optical methods for the diagnosis and monitoring of medical conditions. He is currently the Director of Quantitative Pathology Applications at PerkinElmer where he is the senior application scientist for their multispectral and digital pathology product lines. He is an associate editor of the American Journal of Nuclear Medicine and Molecular Imaging, holds 6 patents, has over 50 publications and has served as an invited speaker, session chair and organizer at a variety of international conferences.

Immunology

Zhao received his MD from Dalian Medical University, China and PhD in Biochemistry from Gifu Medical University, Japan. He completed his post-doctoral fellow training in molecular biology at University of Delaware and in pulmonary diseases at Johns Hopkins University School of Medicine, and became a junior faculty in Department of Medicine at Johns Hopkins University. Following with Drs. Joe Garcia and V. Natarajan, Dr. Zhao moved to University of Chicago and was promoted to Assistant Professor (RA) in Division of Pulmonary and Critical Care. In March 2010, Dr. Zhao joined the Pulmonary, Allergy, and Critical Care faculty at the University of Pittsburgh as an Associate Professor.

Dr. Zhao’s laboratory focuses on role of lysophospholipids in pulmonary epithelial and endothelial inflammation and remodeling

Rina Aharoni completed her doctorate in immunology at the Weizmann Institute of Science in Israel in 1990 on immunomodulation of Multiple Sclerosis (MS) and its animal model Experimental Autoimmune Encephalomyelitis (EAE) as well as on the mechanisms of action of Copaxone (Glatiramer acetate) in these diseases. During her Postdoc in Stanford University (1991-1994), she was the first to show that Copaxone treatment can be applied for additional immunopathological disorders, initially for Graft Versus Host Disease and later for graft rejection. When she returned to the Weizmann Institute (1995 ), her main research involves development of immunomodulatory and neuroprotective approaches and their in situ effect in the Central Nervous System, in particular, the potential for neurogenesis and remyelination. In parallel she continues to study new applications for Copaxone and recently showed its therapeutic potential for the treatment of Inflammatory Bowel Diseases.

Immunomodulation, Neuroprotection, Repair processes in the Central Nervous System, Neurogenesis, Remyelination, Multiple Sclerosis (MS), Experimental Autoimmune Encephalomyelitis (EAE), Copaxone (Glatiramer Acetate, GA), Inflammatory Bowel Diseases (IBD).