José Moisés Laparra Llopis
Pabellón Central del antiguo Hospital de Cantoblanco, Spain
Title: The hope of immunonutrition
Biography
Biography: José Moisés Laparra Llopis
Abstract
Recent data started appearing to show that immunonutritional factors and its influence on and interaction with the gut microbiota, and finally their crosstalk with the host’s immune system are important determinants of the gut-liver axis health, metastasis-initiating cells and cancer promotion. For example, multistructural and multifunctional cell surface molecules such as CD44, also guiding leukocyte extravasation, and the fatty acid receptor CD36 to metastatic penetrance and tumor growth. Moreover, innate immune activators, particularly, agonists of Toll-like receptor (TLR)-4 have been identified as critical players in hepatocellular carcinoma promotion and even modulate the immune-mediated checkpoint blockade. These can be targeted by nutrients, immunologically active, modulating the plasticity of both innate and adaptive immune responses. Personalized nutrition and, moreover, nutrition precision could have a significant impact on health to reduce the risk of metabolic and immune diseases and, particularly those associated to cancer promotion and/or progression. To date, major research interest has been focused on the influence of pre/probiotics, although, additional immunonutritional factors are also relevant even modulating the polarization and activation of immune responses. However, there remain key unanswered questions about immunonutritional factors that overall require a concerted effort to overcome the usually fragmented and compartmentalized approach to address their impact.