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Kamalakannan Rajasekaran


Kamalakannan Rajasekaran

Blood Research Institute, USA

Biography

Kamalakannan Rajasekaran is a Research Scientist at Blood Research Institute, Milwaukee, WI. He obtained his PhD in Immunology from Madurai Kamaraj University. His studies are aimed at deciphering the signaling events that are responsible for NK cell-mediated cytotoxicity and pro-inflammatory cytokine production. His studies have led to the understanding of the role of signaling molecules such as Adap, Carma1 and TAK1 in the production of pro-inflammatory cytokines. His work, published in reputed scientific journals, including Nature Immunology, has paved the way for drafting a molecular ‘blueprint’ for targeting unique signaling molecules to regulate the production of inflammatory cytokines following cell-mediated immunotherapy.

Abstract

Abstract : Defects in nuclear translocation of ERK1/2 and activation of c-Fos in ADAP deficient NK cells correlate with decreased production of pro-inflammatory cytokines