Masoud Edalati
Isfahan University of Medical Sciences, Iran
Title: Prevalence of autoantibodies in patients with multiple sclerosis in Isfahan province of Iran
Biography
Biography: Masoud Edalati
Abstract
Statement of the Problem: Multiple sclerosis (M.S) is a chronic, immune-mediated, relapsing-remitting disorder affecting young adults, which its pathogenesis is still largely unknown. Multiple sclerosis is the commonest cause of neurological disability in young adults. Chronic autoimmune disease like SLE can be mistaken for M.S and should be considered during clinical practice.
Objectives: The purpose of the present study was to determine the prevalence of autoantibodies in patients clinically and radiologically diagnosed with M.S in Isfahan province of Iran.
Methodology & Theoretical Orientation: From September 2015 to September 2016, 269 patients clinically diagnosed with M.S referred by neurologists to Milad Medical Diagnostic Lab to be evaluated for common auto antibodies. Autoantibodies were detected through Elisa and immunofluorescence (I.F) method.
Results: The serum of 10 (3.7%) out of 269 patients clinically diagnosed with M.S disease revealed ANA reactivity followed by 15 (5.57%) showing anti-MOG (anti-myelin oligodendrocyte glycoprotein) and 1 (0.37%) Aquaporin-4 antibodies (NMO-IgG/neuromyelitis optica-IgG) reactivity. The patients were negative for c-ANCA, p-ANCA and APL (anti-phospholipid syndrome) antibodies. The most common ANA immunofluorescence patterns for these patients were homogenous (diffuse 50 %) followed by speckled (40%) and centromere (10%) patterns.
Conclusion & Significance: When assessing patients suspected of having M.S, clinicians should consider immune-mediated disease like SLE, APS, vasculitis and other autoimmune disease, especially if the patient show atypical features for M.S.