Helieh S Oz
UK Medical Center, USA
Title: Chronic immuno-inflammatory diseases and applications for green tea polyphenols
Biography
Biography: Helieh S Oz
Abstract
Millions of people worldwide suffer from chronic inflammatory diseases including periodontitis, hepatitis, pancreatitis, gastrointestinal and neurodegenerative complications which can further lead to malignancies. Inflammation and immune response are required for the tissue defense, regeneration and healing process. Yet, exaggerated and chronic inflammation can advance to life-long debilitation, loss of tissue function and organ failure. Despite the millennial advancements in diagnostic technology and therapeutic modalities, there remains no effective cure for patients who suffer from inflammatory diseases. Therefore, over 40% of patients with inflammatory complications seek some form of complementary and alternative medical (CAM) agents as adjunct therapeutic modalities, to alleviate symptoms and possibly to prevent outcomes of inflammation, whether or not to consent their clinicians. There is not sufficient scientific information or international regulatory enforcements regarding the most available CAM agents which some may interact with patients’ current therapies with severe consequences. One of the most investigated agents is Green tea and it polyphenols (GrTP) with potent antioxidants effects. GrTP have important roles in regulating vital signaling pathways comprise transcription nuclear factor-kappa B mediated I kappa B kinase complex pathways, programmed cell death pathways like caspases and B-cell lymphoma-2 and intervention with the surge of inflammatory markers like cytokines (e.g. TNFα, INF, IL-2, IL-6, IL-10) and production of cyclooxygenase. This workshop will explore mechanism of actions for protective effects of GrTP and some reported adverse effects. In addition, possible applications for GrTP will be presented against chronic inflammatory complications and some food safety applications.