Roald Nezlin
Weizmann institute of Science, Israel
Title: Multiple functions of immunoglobulins in the circulations
Biography
Biography: Roald Nezlin
Abstract
Immunoglobulin molecules perform many functions which are most important for immunity like combining with various antigens with the formation of immune complexes and activation of complement pathway. Serum contains thousands proteins of various origin and properties, synthesized by cells of liver, spleen and other organs and also traces non-self proteins of bacteria and virus origin. Immunoglobulins possess considerable reactivity and form non-immune complexes with many various proteins in the circulation. Immunoglobulin molecules can serve as scavengers removing proteins which are potentially harmful for the body. A good example of this function is the formation of stable IgG complexes with anaphylatoxins, proteins, that are responsible for inflammatory and anaphylactoid reactions leading to various pathologies. More non-immune complexes were described with various activities. For example, some of them can stimulate lymphocytes while others could prevent the interactions of immunoglobulins with cell receptors.