Mahmoud El Feel
Agriculture Research Center, Egypt
Title: Influence of bee venom as immunostimulant activity
Biography
Biography: Mahmoud El Feel
Abstract
The objective of this review was to determine the influence of bee venom (BV) as immunostimulant activity and the immunomodulatory activity of BV on cytokines production. Bee venom acts upon both innate and adaptive immune response. Compounds in bee venom decrease proinflammatory cytokine synthesis (IL-2, IL-12 and IL-4), inactivate both the classical and alternative complement pathway and decrease superoxide anion production in neutrophils. It could be concluded that time and dose-dependent response as well as the type of treated cell line could determine the immunosuppressive and/or immunostimulant property of bee venom that could be effective in future therapeutic strategies.