Idubuibi Cyriacus Oguzie
Anambra State Ministry of Health, Nigeria
Title: Implicating genomics in understanding of new resisitant traits of antibiotics: A critical analysis
Biography
Biography: Idubuibi Cyriacus Oguzie
Abstract
The degree of antibiotic resistance over the years has drawn attention of researches on bacterial genomes as serious scientific tool in the pharmacology. With increasing constant emergence of infectious strains that are resistant to antibiotics, and the cost effect to patients and the research industry, the challenges antibiotic resistance deposed on the health industry is decried in quantum. With the discovery of a new instance of an antibiotic resistant strains; scientific genomic knowledge has become essential pharmacological tool in investigation into the inhibited space of antibiotic resistant mechanism. The paper focuses specific attention on recent research in Genome-scale interrogation as an insight tool into the dynamic mechanisms of antibiotic resistance. The paper further drawn on Transcriptomics as a vehicle for further investigation into resistance mechanism. The argument been, that not only can transcription profiling is successful, but also reveal the role of mfd gene, a factor its believed is involved in strand-specific DNA repair, as it is also seen to be consistent in generation of fluoroquinolone resistance.