Paloma Manea
Grigore T. Popa University of Medicine and Pharmacy, Romania
Title: Correlations between complement C3 and long term outcome of patients diagnosed with renovascular hypertension, complicated with left ventricle systolic dysfunction
Biography
Biography: Paloma Manea
Abstract
The study monithorized 42 patients with renovascular hypertension, due to renal artery stenosis, followed for 24 months. The patients were divided in 2 groups: group A, with systolic dysfunction and group B, without systolic dysfunction. Clinical aproach and laboratory parameters(serum creatinine, creatinine clearance, transaminasis, serum electrolytes,glycemia, lipid profile, complete blood count ,brain natriuretic peptide-BNP, high sensitivity C reactive protein, microalbuminuria, complement C3, electrocardiogram , transthoracic echocardiogram, renal artery sonogram) were performed every 6 months. The statistical analysis revealed a strong correlation between low levels of complement C3 and severe systolic dysfunction: r = 0.826 and p = 0.02. Previous studies noticed the implication of complement C3 in renal ischemia, especiallly in animal models, but it seems that this C3 fraction is also connected with the sesverity of systolic dysfunction, in chronic renal ischemia.. This observation will open new perspectives for establishing a long term prognosis of renovascular hypertension, complicated by systolic heart failure; also, it will offer us a better understanding of this disease , for improving therapeutic strategy.