Immunology

Biography

Biography: Abdul-Rahaman Mubarak

Abstract

Introduction
Human leukocyte antigen G (HLA-G) is a non-classical major histocompatibility complex (MHC) class Ib antigen characterized by a limited polymorphism. The expression of HLA-G at immune privileged sites and its ability to inhibit the effectors functions of immune cells has set HLA-G as a molecule of immune tolerance. This expression pattern is unique among HLA genes and suggests that HLA-G may be involved in interactions that are critical in establishing and/or maintaining pregnancy.

Methods
The study participants include women undergoing spontaneous abortion, non-pregnant women, males and an archive sample of women who had normal vaginal deliveries without any complications and any history of malaria infection from gestation to delivery. The sHLA-G level was measured using BiovendersHLA-G ELISA kit following the manufacturer’s protocol.

Results
sHLA-G levels was found to be higher in women undergoing spontaneous abortion as compared to women who had normal vaginal delivery and non-pregnant women. sHLA-G level was also found to be higher in second trimester as compared to first trimester in both women who had spontaneous abortions and women who had normal delivery.

Conclusion
Although sHLA-G level was found to be higher in women undergoing spontaneous abortion as compared to non-pregnant women and women who had normal delivery, it may not be playing any role in implantation rather playing a role in the maintenance of maternal immune tolerance to foetal antigen after implantation because plasma sHLA-G levels was found to increase with increasing trimester in both women who had normal delivery and women undergoing spontaneous abortion