Rajiv Mahendru
B.P.S. Government Medical College for Women, India
Title: Role of Thyroperoxidase antibodies in unexplained infertility
Biography
Biography: Rajiv Mahendru
Abstract
Thyroid autoimmunity is the most common autoimmune disorder in women of reproductive age, with a prevalence varying between 5 and 15%. Many studies show a significant association between the presence of thyroid autoantibodies, infertility and recurrent pregnancy loss. The aim of study was to find out an association between anti-TPO-Ab, TSH and infertility among female patients attending the Gynaenecologycal OPD for the management of infertility. A cross-Sectional study was conducted for the period of six months from Jan. 2011 to June 2011 in the Department of Obstetrics and Gynaecology in collaboration with the Department of Biochemistry in a rural medical Institute of India. Fifty infertile females of reproductive age group with both primary and secondary infertility were selected for the study and fifty age-matched non pregnant healthy females who had no problem of infertility were taken as controls. Serum anti-TPO Ab, TSH levels were evaluated by Enzyme linked Immunosorbant assay method. The results obtained from the study showed statistical significance between anti-TPO Ab levels, TSH levels, age and infertility in both the groups. The parameters observed may be considered as a valuable aid in investigation and diagnosis of autoimmune thyroid disease in patients with unexplained infertility.