Faten Ismail Mohammed
EL- Minia University, Egypt
Title: Primary Sjögren’s syndrome and B-non Hodgkin lymphoma: Role of CD4+T lymphocytopenia
Biography
Biography: Faten Ismail Mohammed
Abstract
Introduction:
Primary Sjögren's syndrome (pSS) is associated with increased risk of
lympho proliferative malignancy, B- cell Non Hodgkin lymphoma (B-NHL) is the most frequent type.
Objective:
To evaluate CD4+ T lymphocytes distributions in patients with (pSS) and the association of CD4+T lymphocytopenia with the development of (B-NHL).
Patients & Methods:
This study included 8 (pSS) patients associated with B-NHL (group l), 50 (pSS) patients without B-NHL (group ll), and 30 Healthy volunteers served as controls. The frequency of circulating CD4+and CD8+ T lymphocytes distributions and CD4+/CD8+T cell ratio was assessed using Flowcytometry Coulter EPICS-XL and compared between patients groups and controls.
Results:
There was statistically significant CD4+ T lymphocytopenia in (pSS) patients with B-NHL than those without lymphoma and controls (p0.001), moreover, a significant low CD4+/CD8+T cell ratio 0.8 in group1 than group II and controls (p0.001) was found. Significant positive correlations of CD4+T lymphocytopenia with other risk factors (parotid swelling, vasculitis, rheumatoid factors, low complement, cryoglobulinemia were detected.
Conclusion:
CD4+T lymphocytopenia is associated with B-NHL developed in patients with pSS and can be considered as an important predictor of lymphoma