Immunology

Biography

Biography: Reva Sharan Thakur

Abstract

Introduction: Malaria is vector born diseases caused by plasmodium species, survive and replicated into two (Human and Mosquito) host systems. In human, malaria parasite escapes immune response and replicate. In our experiments we found that, accumulation of mesenchymal stem cells in the secondary lymphoid organ using the mouse model of malaria with Plasmodium berghei and imbalance of immune cells during malaria infection. We used rodent malaria parasite to understand host systems. Surprisingly we found that imbalanced numbers of immune cells with the infection were unable to protect. A part from these cells types, increased number of mesenchymal stem cells were unable to protect during malaria infection. Mesenchymal stromal cells or mesenchymal stem cells (MSCs) are multipotent in nature and able to differentiate into different cell types. These differentiating cells were able to express Notch1 may underline mechanism of action of mesenchymal stem cells by production of soluble factors such as IL6 and MIP1a. We also found that these Sca-1+ cells were able to modulate immune response by modulating regulatory T cells with disease progression. Regulatory T cells modulation also dependent upon expression of Notch-1+ cells. Sca-1+ mesenchymal stem cells able to express Notch-1+ during infection, may suggesting that partially Sca-1+Notch-1+ mesenchymal stem cell dependent protection during malaria infection.