Nurieva Roza Insafetdinovna
University of Texas MD Anderson Cancer Center, USA
Title: BATF is essential for IL-4 expression in T follicular helper cells
Biography
Biography: Nurieva Roza Insafetdinovna
Abstract
Apart from T helper (Th)-2 cells, T follicular helper (Tfh) cells are a major class of IL-4 producing T cells, required for regulation of type 2 humoral immunity. Although the transcriptional control of IL-4 has been an area of extensive investigation, the precise regulation mechanism of IL-4 production in Tfh cells remains mainly unknown. In the current study, we found that the transcription factor BATF, a member of the AP-1/Jun family is essential for IL-4 expression in Tfh cells rather than in canonical Th2 cells. Functionally, BATF in cooperation with Interferon regulatory factor (IRF) 4 along with Stat3 and Stat6 trigger IL-4 production in Tfh cells by directly binding to and activation of the CNS2 region in the IL-4 locus. In addition, Batf-to-c-Maf signaling is an important determinant of IL-4 expression in Tfh cells. BATF deficiency impairs the generation of IL-4 producing Tfh cells that results in protection against allergic asthma. IL-4 acts as an autocrine factor in controlling BATF-mediated IL-4 expression in Tfh cells. Our results thus indicate a critical role of BATF in promoting the generation of pro-allergic IL-4 producing Tfh cells.
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