Jose Moises Laparra Llopis
Pabellon Central del antiguo Hospital de Cantoblanco, Spain
Biography
Dr. Laparra Llopis JM holds a PhD in Pharmacy gained during his stay at the High Research Council of the Spanish Government (CSIC). His scientific career is focused on the field of intestinal homeostasis and the cross-talk within gut-liver axis. The novelty and scientific and social impact of his studies was used by the European Food Safety Authority to establish recommendations concerning staple foods. He held a leading position on prebiotic research awarded by The Fulbright Commission to conduct postdoctoral research in the Food Science Department at Cornell University (NY, USA). After his relocation to CSIC, a continuous contact and interaction with internationally renowned enterprises and research groups constitutes a constant in Dr Laparra’s career where he took major responsibilities overseeing several precompetitive funded projects. This experience favored his incorporation to the Institute of Translational Immunology at the University Medical Center of Mainz University (GER) as independent researcher. Currently, as senior researcher at IMDEA Food (Madrid, SPN) he develops immunonutritional-based precision strategies to selectively modulate innate immune responses preventing/treating the risk for/severity of liver-related metabolic and immune diseases and hepatocellular carcinoma. Particularly, his research approaches naturally occurring food components with powerful immunostimulatory property of toll-like receptors (TLRs) for active immunotherapy against liver metabolic dysfunction and cancer promotion. Here, Dr Laparra’s research efforts are focused on the impact and functional differentiation and polarization of macrophages, as relevant prognostic biomarkers of tissue damage and tumor progression. He develops strategies to selectively modulate metabolic programming of antigen presenting cells that have important roles in the regulation of CD4+ T cells priming as well as immune checkpoint blockade. Thereby, preventing effector CD8+ T cells exhaustion that helps developing longer anti-tumoral response(s). Dr Laparra has published over 70 scientific articles and several book chapters.
Abstract
Abstract : The hope of immunonutrition